Dimethylamine → HCID 53467784, compound

HRID 1055240Notes

Reaction equation

HRID 1055240 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[C:7]([O:9]CC)=O.[CH3:12][NH:13][CH3:14]>C(O)C>[CH3:12][N:13]([CH3:14])[C:7]([CH:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1])=[O:9]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 69136Ethyl 2-oxocyclopentanecarboxylate

Product 1

HCID 53467784HCID 53467784, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.337 mol (50 ml) of ethyl 2-oxocyclopentanecarboxylate and 152 ml 33% dimethylamine solution in ethanol were stirred in a pressure reactor for 4 h at 110° C. The reaction mixture was then evaporated to dryness and the crude product was purified over 400 g silica gel with ethyl acetate/hexane 1/1. 17.7 g of the title compound were obtained.

Workup

  1. customThe reaction mixture was then evaporated to dryness
  2. customthe crude product was purified over 400 g silica gel with ethyl acetate/hexane 1/1

Sources & evidence

ORD record
ord-9622f3712ed34a059882b401f67298ff
Source dataset
uspto-grants-2016_07
Patent number
US09394324B2

Reaction notes

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