Isobutylamine → HCID 5106679, compound
Reaction equation
[CH2:1]([NH2:5])[CH:2]([CH3:4])[CH3:3].[CH2:6]=[C:7]1[O:11][C:9](=[O:10])[CH2:8]1>O1CCCC1>[CH3:3][CH:2]([CH3:4])[CH2:1][NH:5][C:9](=[O:10])[CH2:8][C:7](=[O:11])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 18.20 g (0.25 mol) isobutylamine in 50 ml tetrahydrofuran was added dropwise to a solution of 20 g of diketene (0.24 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue is recrystallized from 100 ml of ethyl acetate. This gave 26.93 g (0.17 mol, 72% yield) of a white solid.
Workup
- customThe reaction mixture was evaporated
- customthe residue is recrystallized from 100 ml of ethyl acetate
Sources & evidence
- ORD record
- ord-b3c56c60e2b544749cc02d77c7b57fed
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394324B2
Reaction notes
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