HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → HCID 53467353, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | Methyl 4-methoxyacetoacetate | HCID 123500 | — |
| Product | HCID 53467353 | HCID 53467353 | 32.4% |
Reaction Steps
0.34 mol (48.7 g) of methyl 4-methoxy-acetoacetate and 0.36 mol (36.0 g) of 4-hydroxypiperidine were stirred for 5 h at 120° C. at a Dean-Stark apparatus. 45 g of the crude product was purified over 1 kg of silica gel with ethyl acetate/ethanol 9/1. 23.7 g of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394324B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-938f627bfcbd4a0f8e0643a7fb9e4746 |
| Source note | uspto-grants-2016_07 |