Piperidin-4-ol → HCID 53467353, compound

HRID 1055254Notes

Reaction equation

HRID 1055254 reaction equation
[CH3:1][O:2][CH2:3][C:4](=[O:10])[CH2:5][C:6]([O:8]C)=O.[OH:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[OH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:6](=[O:8])[CH2:5][C:4](=[O:10])[CH2:3][O:2][CH3:1])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 123500Methyl 4-methoxyacetoacetate

Product 1

HCID 53467353HCID 53467353, compoundYield 32.4%

Procedure

0.34 mol (48.7 g) of methyl 4-methoxy-acetoacetate and 0.36 mol (36.0 g) of 4-hydroxypiperidine were stirred for 5 h at 120° C. at a Dean-Stark apparatus. 45 g of the crude product was purified over 1 kg of silica gel with ethyl acetate/ethanol 9/1. 23.7 g of the title compound were obtained.

Workup

  1. custom45 g of the crude product was purified over 1 kg of silica gel with ethyl acetate/ethanol 9/1

Sources & evidence

ORD record
ord-938f627bfcbd4a0f8e0643a7fb9e4746
Source dataset
uspto-grants-2016_07
Patent number
US09394324B2

Reaction notes

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