反应详情

In a 1000 mL round flask, 9,9-dihexyl-2-methyl-2,3-dihydrocyclopenta[b]fluoren-1(9H)-one (85 g, 211.1 mmol) was dissolved in 400 mL of THF and 400 mL of ethanol and then stirred. Sodium borohydride (NaBH4) (10 g, 265.0 mmol) was added to the reactant in five lots, and then stirred for 12 hours. After removal of the solvent, the resultant material was dissolved in ethylacetate, and then washed with water three times. The organic layer was dried over magnesium sulfate, followed by removal of volatile materials and drying, thereby obtaining 82.0 g of 9,9-dihexyl-2-methyl-1,2,3,9-tetrahydrocyclopenta[b]fluoren-1-ol (yield: 96.0%) (two isomers) as highly viscous oil.

1. customAfter removal of the solvent
2. dissolutionthe resultant material was dissolved in ethylacetate
3. washwashed with water three times
4. dry with materialThe organic layer was dried over magnesium sulfate
5. customfollowed by removal of volatile materials
6. customdrying