反应详情

Lithium aluminum hydride (LAH, 1 M in THF, 2 mL, 2.0 mmol) was added to solution of methyl 2-(methylsulfonyl)isoindoline-4-carboxylate in THF (15 mL). After 10 h the mixture was diluted with 5% NaOH solution and extracted with EtOAc. The combined organic extracts were dried over MgSO4 and concentrated. The residue was recrystallized from DCM to give the title compound (200 mg, 61%) as a grey solid.

1. extractionextracted with EtOAc
2. dry with materialThe combined organic extracts were dried over MgSO4
3. concentrationconcentrated
4. customThe residue was recrystallized from DCM