反应详情

A solution of (S)-tert-butyl 5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate (1.803 g, 3.42 mmol) in 4 M HCl in dioxane (17.1 mL) was stirred at RT for 2 h. The mixture was concentrated and the residue triturated with Et2O to provide (S)-3-amino-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one hydrochloride (1.415 g, 89%) as an off-white solid. MS m/z 427/429 MH

1. concentrationThe mixture was concentrated
2. customthe residue triturated with Et2O