Hydrochloric Acid → HCID 118574162, compound

HRID 1055475Notes

Reaction equation

HRID 1055475 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([CH2:12][N:13]1[C:19](=[O:20])[C@@H:18]([NH:21]C(=O)OC(C)(C)C)[CH2:17][O:16][C:15]3[CH:29]=[CH:30][CH:31]=[CH:32][C:14]1=3)=[C:7]([O:33][CH3:34])[CH:6]=[CH:5]2.[ClH:35]>O1CCOCC1>[ClH:35].[NH2:21][C@H:18]1[CH2:17][O:16][C:15]2[CH:29]=[CH:30][CH:31]=[CH:32][C:14]=2[N:13]([CH2:12][C:8]2[C:9]3[C:4](=[CH:3][C:2]([Br:1])=[CH:11][CH:10]=3)[CH:5]=[CH:6][C:7]=2[O:33][CH3:34])[C:19]1=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118574202(S)-tert-butyl 5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate

Product 1

HCID 118574162HCID 118574162, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (S)-tert-butyl 5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylcarbamate (1.803 g, 3.42 mmol) in 4 M HCl in dioxane (17.1 mL) was stirred at RT for 2 h. The mixture was concentrated and the residue triturated with Et2O to provide (S)-3-amino-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one hydrochloride (1.415 g, 89%) as an off-white solid. MS m/z 427/429 MH

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue triturated with Et2O

Sources & evidence

ORD record
ord-478e8f14819245eeb4e9321a672d550a
Source dataset
uspto-grants-2016_07
Patent number
US09394263B2

Reaction notes

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