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HRID1055479

反应详情

EQUATION

反应方程式

HRID 1055479 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O
HCID131736374

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](N)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.Cl
HCID90038089

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of tert-butyl (S)-1-((S)-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylamino)-1-oxobutan-2-ylcarbamate (430 mg, 702 μmol) in 4 M HCl in dioxane (3.51 mL) was stirred at RT for 1 h, and concentrated. the residue was triturated with Et2O to provide (S)-2-amino-N -((S)-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)butanamide hydrochloride (357 mg, 93%) as a white solid.

WORKUP

后处理

  1. concentrationconcentrated
  2. customthe residue was triturated with Et2O