反应详情

5.51 g (29.6 mmol) of 3-bromo-4-methylaniline were dissolved in 127 ml of dichloromethane, 6.18 g (29.6 mmol) of 3-(trifluoromethyl)benzoyl chloride and 4.54 ml (32.6 mmol) of triethylamine were added and the mixture was stirred at RT for 30 min. All volatile components were removed under reduced pressure and the residue was suspended in 50 ml of methanol. The solid was filtered off and the filtrate was stirred into 100 ml of 1 M hydrochloric acid. The precipitate formed was filtered off, washed with water and dried. This gave 7.05 g (90% pure, 60% of theory) of the title compound.

1. customAll volatile components were removed under reduced pressure
2. filtrationThe solid was filtered off
3. stirringthe filtrate was stirred into 100 ml of 1 M hydrochloric acid
4. customThe precipitate formed
5. filtrationwas filtered off
6. washwashed with water
7. customdried