HRID1055668

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67214325

未命名化合物

结构：COc1ccc(Cn2cc(-c3cc4n(-c5cc(N)ccc5C)ccn4n3)cn2)cc1.O=C(O)C(F)(F)F

HCID89700026

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cn2cc(-c3cc4n(-c5cc(NC(=O)c6cc(-n7ccnc7C)cc(C(F)(F)F)c6)ccc5C)ccn4n3)cn2)cc1

HCID89700195

未命名化合物

PROCEDURE

实验过程

60 mg (0.12 mmol) of the compound of Example 8A and 31.6 mg (0.12 mmol) of 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid [lit.: WO 2004/005281-A1, Example 91b] were reacted and worked up analogously to the procedure of Example 48A. This gave 61 mg (77% of theory) of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-74a346730f1241fca224e1a6be49926c
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394309B2
来源说明: uspto-grants-2016_07

反应 SMILES

FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[CH:37]=[CH:36][C:13]([CH2:14][N:15]2[CH:19]=[C:18]([C:20]3[CH:21]=[C:22]4[N:27]([C:28]5[CH:29]=[C:30]([CH:32]=[CH:33][C:34]=5[CH3:35])[NH2:31])[CH:26]=[CH:25][N:23]4[N:24]=3)[CH:17]=[N:16]2)=[CH:12][CH:11]=1.[CH3:38][C:39]1[N:40]([C:44]2[CH:45]=[C:46]([CH:50]=[C:51]([C:53]([F:56])([F:55])[F:54])[CH:52]=2)[C:47](O)=[O:48])[CH:41]=[CH:42][N:43]=1>>[CH3:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][N:15]2[CH:19]=[C:18]([C:20]3[CH:21]=[C:22]4[N:27]([C:28]5[CH:29]=[C:30]([NH:31][C:47](=[O:48])[C:46]6[CH:50]=[C:51]([C:53]([F:54])([F:55])[F:56])[CH:52]=[C:44]([N:40]7[CH:41]=[CH:42][N:43]=[C:39]7[CH3:38])[CH:45]=6)[CH:32]=[CH:33][C:34]=5[CH3:35])[CH:26]=[CH:25][N:23]4[N:24]=3)[CH:17]=[N:16]2)=[CH:36][CH:37]=1