HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate → 3-tert-Butyl-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pyrrolidin-1-ylmethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate | HCID 89699809 | — |
| Reactant | 3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline trifluoroacetate | HCID 89700026 | — |
| Product | 3-tert-Butyl-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pyrrolidin-1-ylmethyl)benzamide | HCID 89699652 | — |
Reaction Steps
70 mg (0.14 mmol) of the compound of Example 8A and 51 mg (0.14 mmol) of the compound of Example 22A were reacted analogously to the procedure of Example 48A. This gave 83 mg (88% pure, 83% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394309B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-eb0c4668826647efa5e0f58036f912f5 |
| Source note | uspto-grants-2016_07 |