3-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetate → N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055671Notes

Reaction equation

HRID 1055671 reaction equation
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[CH3:39][N:40]1[CH2:45][CH2:44][N:43]([C:46]2[CH:47]=[C:48]([CH:52]=[C:53]([S:55]([F:60])([F:59])([F:58])([F:57])[F:56])[CH:54]=2)[C:49](O)=[O:50])[CH2:42][CH2:41]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([NH:24][C:49](=[O:50])[C:48]6[CH:52]=[C:53]([S:55]([F:60])([F:56])([F:57])([F:58])[F:59])[CH:54]=[C:46]([N:43]7[CH2:42][CH2:41][N:40]([CH3:39])[CH2:45][CH2:44]7)[CH:47]=6)[CH:25]=[CH:26][C:27]=5[CH3:28])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 896995603-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetateHCID 896998613-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline

Product 1

HCID 89699504N-(3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-3-(4-methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

Procedure

70 mg (0.17 mmol) of the compound of Example 9A and 78 mg (0.17 mmol) of the compound of Example 17A were reacted and worked up analogously to the procedure of Example 48A. This gave 125 mg (95% of theory) of the title compound.

Sources & evidence

ORD record
ord-f7b7093cbb9b46f4bc8e89567ca48434
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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