反应详情

At 90° C., 115 mg (0.23 mmol) of the compound of Example 56A were stirred in 1.5 ml of trifluoroacetic acid for 60 min. The reaction was then concentrated under reduced pressure and the residue was purified by preparative HPLC (Method 21). The product fractions were combined, concentrated almost completely under reduced pressure and made alkaline with a little saturated aqueous sodium bicarbonate solution. The resulting precipitate was filtered off, washed with water and dried under high vacuum. This gave 60 mg (46% of theory) of the title compound.

1. concentrationThe reaction was then concentrated under reduced pressure
2. customthe residue was purified by preparative HPLC (Method 21)
3. concentrationconcentrated almost completely under reduced pressure
4. filtrationThe resulting precipitate was filtered off
5. washwashed with water
6. customdried under high vacuum