Trifluoroacetic acid → 3-Methoxy-N-{4-methyl-3-[3-methyl-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	3-Methoxy-5-(pentafluoro-lambda6-sulphanyl)benzoic acid	HCID 89699717	—
Reactant	3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline	HCID 89699861	—
Product	3-Methoxy-N-{4-methyl-3-[3-methyl-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide	HCID 136630241	—

Reaction Steps

60 mg (0.15 mmol) of the compound of Example 9A and 40 mg (0.15 mmol) of the compound of Example 25A were reacted analogously to the procedure of Example 10, except that here the reaction was stirred with trifluoroacetic acid at 80° C. only for 3 h (instead of 6 h). This gave 36 mg (43% of theory) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394309B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-532c8479014d4017b98bba5a2e9d175b
Source note	uspto-grants-2016_07