Trifluoroacetic acid → 3-Methoxy-N-{4-methyl-3-[3-methyl-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide
Reaction equation
COC1C=CC(C[N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=CC=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:48])([F:47])([F:46])([F:45])[F:44])[CH:42]=1)[C:37](O)=[O:38].FC(F)(F)C(O)=O>>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:48])([F:44])([F:45])([F:46])[F:47])[CH:42]=1)[C:37]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([N:20]2[C:15]3[N:16]([N:17]=[C:13]([C:11]4[CH:12]=[N:8][NH:9][CH:10]=4)[CH:14]=3)[C:18]([CH3:29])=[CH:19]2)[CH:22]=1)=[O:38]Participants
4
Reactant 3
Product 1
Procedure
60 mg (0.15 mmol) of the compound of Example 9A and 40 mg (0.15 mmol) of the compound of Example 25A were reacted analogously to the procedure of Example 10, except that here the reaction was stirred with trifluoroacetic acid at 80° C. only for 3 h (instead of 6 h). This gave 36 mg (43% of theory) of the title compound.
Sources & evidence
- ORD record
- ord-532c8479014d4017b98bba5a2e9d175b
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394309B2
Reaction notes
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