HRID1055711

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67214325

未命名化合物

结构：COc1ccc(Cn2cc(-c3cc4n(-c5cc(N)ccc5C)cc(C)n4n3)cn2)cc1

HCID89699861

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2cc(-n3ccnc3C)cc(C(F)(F)F)c2)cc1-n1cc(C)n2nc(-c3cn[nH]c3)cc12

HCID136630244

未命名化合物

PROCEDURE

实验过程

70 mg (0.17 mmol) of the compound of Example 9A and 50 mg (0.19 mmol) of 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid [lit.: WO 2004/005281-A1, Example 91b] were reacted analogously to the procedure of Example 13. This gave 58 mg (71% of theory) of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6395b6fb42704feea30818a945d7791e
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394309B2
来源说明: uspto-grants-2016_07

反应 SMILES

COC1C=CC(C[N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=CC=1.[CH3:32][C:33]1[N:34]([C:38]2[CH:39]=[C:40]([CH:44]=[C:45]([C:47]([F:50])([F:49])[F:48])[CH:46]=2)[C:41](O)=[O:42])[CH:35]=[CH:36][N:37]=1>>[CH3:32][C:33]1[N:34]([C:38]2[CH:39]=[C:40]([CH:44]=[C:45]([C:47]([F:50])([F:48])[F:49])[CH:46]=2)[C:41]([NH:24][C:23]2[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([N:20]3[C:15]4[N:16]([N:17]=[C:13]([C:11]5[CH:12]=[N:8][NH:9][CH:10]=5)[CH:14]=4)[C:18]([CH3:29])=[CH:19]3)[CH:22]=2)=[O:42])[CH:35]=[CH:36][N:37]=1