HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzoic acid → 3-(2-Methyl-1H-imidazol-1-yl)-N-{4-methyl-3-[3-methyl-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]-pyrazol-1-yl]phenyl}-5-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-benzoic acid | HCID 67214325 | — |
| Reactant | 3-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline | HCID 89699861 | — |
| Product | 3-(2-Methyl-1H-imidazol-1-yl)-N-{4-methyl-3-[3-methyl-6-(1H-pyrazol-4-yl)-1H-imidazo[1,2-b]-pyrazol-1-yl]phenyl}-5-(trifluoromethyl)benzamide | HCID 136630244 | — |
Reaction Steps
70 mg (0.17 mmol) of the compound of Example 9A and 50 mg (0.19 mmol) of 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid [lit.: WO 2004/005281-A1, Example 91b] were reacted analogously to the procedure of Example 13. This gave 58 mg (71% of theory) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394309B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-6395b6fb42704feea30818a945d7791e |
| Source note | uspto-grants-2016_07 |