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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1055737Generated: October 30, 2026

3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate → 3-tert-Butyl-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pyrrolidin-1-ylmethyl)benzamide

https://huagongshe.com/reaction/1055737

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetateHCID 89699809—
Reactant4-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]anilineHCID 89700023—
Product3-tert-Butyl-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pyrrolidin-1-ylmethyl)benzamideHCID 89699759—

Reaction Steps

35 mg (0.12 mmol) of the compound of Example 6A and 47 mg (0.12 mmol) of the compound of Example 22A were reacted and worked up analogously to the procedure of Example 16. This gave 55 mg (95% pure, 81% of theory) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09394309B2
Source datasetuspto-grants-2016_07
ORD IDord-f938a31b79ff49c0b537506c507a0489
Source noteuspto-grants-2016_07