2-(tert-Butyl)isonicotinic acid → HCID 89699997, compound

HRID 1055738Notes

Reaction equation

HRID 1055738 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[C:23]([C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][N:35]=1)[C:30](O)=[O:31])([CH3:26])([CH3:25])[CH3:24]>>[C:23]([C:27]1[CH:28]=[C:29]([CH:33]=[CH:34][N:35]=1)[C:30]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:31])([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 6932922-(tert-Butyl)isonicotinic acidHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 89699997HCID 89699997, compound

Procedure

60 mg (0.21 mmol) of the compound of Example 6A and 37 mg (0.21 mmol) of 2-tert-butyliso-nicotinic acid were reacted and worked up analogously to the procedure of Example 33, except that in this case the reaction time was 16 h. This gave 13 mg (96% pure, 13% of theory) of the title compound.

Sources & evidence

ORD record
ord-762017741e944bcd95554c67d8a59aea
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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