HCID 89699811, compound → HCID 89699706, compound

HRID 1055752Notes

Reaction equation

HRID 1055752 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.[C:23]([C:25]1[CH:26]=[C:27]([CH:31]=[C:32]([C:34]2([OH:38])[CH2:37][CH2:36][CH2:35]2)[CH:33]=1)[C:28](O)=[O:29])#[N:24]>>[C:23]([C:25]1[CH:26]=[C:27]([CH:31]=[C:32]([C:34]2([OH:38])[CH2:35][CH2:36][CH2:37]2)[CH:33]=1)[C:28]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:29])#[N:24]

Participants

3

Reactant 2

HCID 89699811HCID 89699811, compoundHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Product 1

HCID 89699706HCID 89699706, compound

Procedure

Analogously to the process described in Example 26, 80 mg (0.276 mmol) of the compound of Example 6A and 60 mg (0.276 mmol) of the compound of Example 73A gave 115 mg (82% of theory, 96% pure) of the title compound. In this case, the reaction time was 1 h. Final trituration of the product was carried out using a mixture of 10 ml of pentane and 2 ml of diisopropyl ether.

Sources & evidence

ORD record
ord-ae6ef995d1fd4a0f9310dea8e02e2c68
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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