3-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acid → HCID 89700174, compound

HRID 1055764Notes

Reaction equation

HRID 1055764 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[C:5]([CH3:23])=[CH:4][CH:3]=1.[C:24]([C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([S:35]([F:40])([F:39])([F:38])([F:37])[F:36])[CH:34]=1)[C:29](O)=[O:30])#[N:25]>>[C:24]([C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([S:35]([F:39])([F:40])([F:36])([F:37])[F:38])[CH:34]=1)[C:29]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:23])=[C:6]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[C:7]=1[OH:8])=[O:30])#[N:25]

Participants

3

Reactant 2

HCID 896998123-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acidHCID 89699966HCID 89699966, compound

Product 1

HCID 89700174HCID 89700174, compound

Procedure

Analogously to the process described in Example 155, 37 mg (0.109 mmol) of the compound of Example 82A and 28 mg (0.104 mmol) of the compound of Example 23A were reacted to give 9 mg (15% of theory) of the title compound. Here, preparative HPLC purification was carried out according to Method 37.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6c32df39ac6c4632bf9fd485dc6338ba
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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