3-[7-Fluoro-6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-4-methylaniline → HCID 89699742, compound

HRID 1055766Notes

Reaction equation

HRID 1055766 reaction equation
[F:1][C:2]1[C:6]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:5][N:4]2[CH:13]=[CH:14][N:15]([C:16]3[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=3[CH3:23])[NH2:19])[C:3]=12.[C:24]([C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([S:35]([F:40])([F:39])([F:38])([F:37])[F:36])[CH:34]=1)[C:29](O)=[O:30])#[N:25]>>[C:24]([C:26]1[CH:27]=[C:28]([CH:32]=[C:33]([S:35]([F:39])([F:40])([F:36])([F:37])[F:38])[CH:34]=1)[C:29]([NH:19][C:18]1[CH:20]=[CH:21][C:22]([CH3:23])=[C:16]([N:15]2[C:3]3[N:4]([N:5]=[C:6]([C:7]4[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=4)[C:2]=3[F:1])[CH:13]=[CH:14]2)[CH:17]=1)=[O:30])#[N:25]

Participants

3

Reactant 2

HCID 896997403-[7-Fluoro-6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-4-methylanilineHCID 896998123-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acid

Product 1

HCID 89699742HCID 89699742, compound

Procedure

Analogously to the process described in Example 126, 60 mg (0.195 mmol) of the compound of Example 83A and 53 mg (0.195 mmol) of the compound of Example 23A gave 61 mg (55% of theory) of the title compound. The product obtained from the preparative HPLC purification was dissolved in a little methanol and passed through a bicarbonate cartridge (from Polymerlabs, Stratospheres SPE, PL-HCO3 MP SPE, capacity 0.9 mmol). After concentration of the eluate, the residue was dried under high vacuum.

Sources & evidence

ORD record
ord-1bd0ca591dfe4bebb5125e4a86c2600b
Source dataset
uspto-grants-2016_07
Patent number
US09394309B2

Reaction notes

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