反应详情

温度

80 °C

(E)-Ethyl 4-(N-formylformamido)but-2-enoate (3.04 g, 16.43 mmol) was treated with EtOH (20 mL) and TFA (10.0 mL, 130 mmol), fitted with a reflux condenser and heated to 80° C. for 21 h. The mixture was concentrated on the rotovap and dried under high vacuum affording crude (E)-ethyl 4-aminobut-2-enoate 2,2,2-trifluoroacetate as a light yellow viscous liquid: m/z (ESI, +ve ion) 130.1 (M+H)+. The crude material was used in the next step without further purification.

1. customfitted with a reflux condenser
2. concentrationThe mixture was concentrated on the rotovap
3. customdried under high vacuum