8-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine → 1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone

HRID 1056110Notes

Reaction equation

HRID 1056110 reaction equation
[C:1]([NH:5][C:6]1[C:7]([CH3:20])=[N:8][C:9]2[C:14]([N:15]=1)=[C:13]([C:16](=[O:18])[CH3:17])[C:12]([F:19])=[CH:11][CH:10]=2)([CH3:4])([CH3:3])[CH3:2].BrC1C(F)=CC=C2C=1N=C(NC1(C)CC1)C(C)=N2>>[F:19][C:12]1[C:13]([C:16](=[O:18])[CH3:17])=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:20])[C:6]([NH:5][C:1]1([CH3:4])[CH2:3][CH2:2]1)=[N:15]2

Participants

3

Reactant 2

HCID 897820488-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amineHCID 897821331-(3-(Tert-butylamino)-6-fluoro-2-methylquinoxalin-5-yl)ethanone

Product 1

HCID 897818741-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanoneYield 60%

Procedure

1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone (610b) (740 mg, 60% yield) as a light yellow solid was prepared according to the procedure described for Intermediate 605b, using 8-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine (610a) (1.39 g, 4.49 mmol) as the starting material. m/z (ESI, +ve ion) 274.2 (M+H)+.

Sources & evidence

ORD record
ord-26296aaf23fb46bb98d10deb07336ca2
Source dataset
uspto-grants-2016_07
Patent number
US09394297B2

Reaction notes

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