HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine → 1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine | HCID 89782048 | — |
| Reactant | 1-(3-(Tert-butylamino)-6-fluoro-2-methylquinoxalin-5-yl)ethanone | HCID 89782133 | — |
| Product | 1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone | HCID 89781874 | 60% |
Reaction Steps
1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone (610b) (740 mg, 60% yield) as a light yellow solid was prepared according to the procedure described for Intermediate 605b, using 8-bromo-7-fluoro-3-methyl-N-(1-methylcyclopropyl)quinoxalin-2-amine (610a) (1.39 g, 4.49 mmol) as the starting material. m/z (ESI, +ve ion) 274.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394297B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-26296aaf23fb46bb98d10deb07336ca2 |
| Source note | uspto-grants-2016_07 |