1-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone → 2-Bromo-1-(6-fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone

HRID 1056111Notes

Reaction equation

HRID 1056111 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([NH:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:9]([CH3:16])=[N:10]2)=[O:4].FC1C(C(=O)C)=C2C(=CC=1)N=C(C)C(NC1(C)CC1)=N2>>[Br:1][CH2:2][C:3]([C:5]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]2[C:6]=1[N:7]=[C:8]([NH:17][C:18]1([CH3:21])[CH2:20][CH2:19]1)[C:9]([CH3:16])=[N:10]2)=[O:4]

Participants

3

Reactant 2

HCID 897818741-(6-Fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanoneHCID 897819262-Bromo-1-(3-(tert-butylamino)-6-fluoro-2-methylquinoxalin-5-yl)ethanone

Product 1

HCID 897821362-Bromo-1-(6-fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanoneYield 56%

Procedure

2-Bromo-1-(6-fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone (610) (846 mg, 56% yield) as a light yellow solid was prepared according to the procedure described for Intermediate 605, using 1-(6-fluoro-2-methyl-3-((1-methylcyclopropyl)amino)quinoxalin-5-yl)ethanone (610b) (1.18 g, 4.31 mmol) as the starting material. m/z (ESI, +ve ion) 352.1/354.1 (M+H)+.

Sources & evidence

ORD record
ord-3c6b873cd9c447bf8367d6aca606b726
Source dataset
uspto-grants-2016_07
Patent number
US09394297B2

Reaction notes

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