1,2-Dichloroethane → N2-{4-[4-amino-1-(1-ethyl-4-piperidyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}-1-methyl-1H-2-indolecarboxamide

HRID 105613Notes

Reaction equation

HRID 105613 reaction equation
[C:41]([O:42][BH-:43]([O:44][C:45](=[O:46])[CH3:47])[O:48][C:49](=[O:50])[CH3:51])(=[O:52])[CH3:53].[CH:38]([CH3:39])=[O:40].[Cl:55][CH2:56][CH2:57][Cl:58].[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:32]1[CH2:33][CH2:34][NH:35][CH2:36][CH2:37]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:30][CH3:31])[c:14]([NH:17][C:18](=[O:19])[c:20]2[n:21]([CH3:29])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[cH:28]2)[cH:15][cH:16]1.[Na+:54]>>[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:32]1[CH2:33][CH2:34][N:35]([CH2:38][CH3:39])[CH2:36][CH2:37]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:30][CH3:31])[c:14]([NH:17][C:18](=[O:19])[c:20]2[n:21]([CH3:29])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[cH:28]2)[cH:15][cH:16]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 177AcetaldehydeHCID 923Sodium ionHCID 2724942TriacetoxyborohydrideHCID 20817350HCID 20817350, compound

Product 1

HCID 22346663N2-{4-[4-amino-1-(1-ethyl-4-piperidyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}-1-methyl-1H-2-indolecarboxamide

Sources & evidence

ORD record
ord-ebfe650ba8994de2a12ad00189f9be9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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