1-Methylcyclobutan-1-amine hydrochloride → 8-Bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclobutyl)amino)quinazolin-4(3H)-one
Reaction equation
[Br:1][C:2]1[C:3]([F:21])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([NH:12][C:13]1([CH3:16])[CH2:15][CH2:14]1)[N:8]([CH:17]1[CH2:19][CH2:18]1)[C:7]2=[O:20].Br[C:23]1C(F)=CC=C2C=1N=C(Cl)N(C1CC1)C2=O.Cl.CC1(N)CCC1>>[Br:1][C:2]1[C:3]([F:21])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([NH:12][C:13]1([CH3:16])[CH2:14][CH2:15][CH2:23]1)[N:8]([CH:17]1[CH2:18][CH2:19]1)[C:7]2=[O:20]Participants
4
Reactant 3
Product 1
Procedure
8-Bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclobutyl)amino)quinazolin-4(3H)-one (498a) was prepared according to the procedures described for Intermediate 495a, using 8-bromo-2-chloro-3-cyclopropyl-7-fluoroquinazolin-4(3H)-one (721) and 1-methylcyclobutanamine hydrochloride (Oakwood Chemical) as the starting materials. MS (ESI, pos. ion) m/z: 366.0/368.0 (M+1).
Sources & evidence
- ORD record
- ord-cd1657a0f533463c90fba4d9ba8542e2
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394297B2
Reaction notes
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