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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1056383Generated: November 3, 2026

1-Methylcyclobutan-1-amine hydrochloride → 8-Bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclobutyl)amino)quinazolin-4(3H)-one

https://huagongshe.com/reaction/1056383

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methylcyclobutan-1-amine hydrochlorideHCID 18332449—
Reactant8-bromo-2-chloro-3-cyclopropyl-7-fluoroquinazolin-4(3H)-oneHCID 89781975—
Reactant8-bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-oneHCID 89782331—
Product8-Bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclobutyl)amino)quinazolin-4(3H)-oneHCID 89781922—

Reaction Steps

8-Bromo-3-cyclopropyl-7-fluoro-2-((1-methylcyclobutyl)amino)quinazolin-4(3H)-one (498a) was prepared according to the procedures described for Intermediate 495a, using 8-bromo-2-chloro-3-cyclopropyl-7-fluoroquinazolin-4(3H)-one (721) and 1-methylcyclobutanamine hydrochloride (Oakwood Chemical) as the starting materials. MS (ESI, pos. ion) m/z: 366.0/368.0 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09394297B2
Source datasetuspto-grants-2016_07
ORD IDord-cd1657a0f533463c90fba4d9ba8542e2
Source noteuspto-grants-2016_07