反应详情

To a 100 mL round-bottomed flask was added 2-amino-3-iodo-N-(3-(methylthio)propyl)benzamide (1.25 g, 3.57 mmol) and triphosgene (0.185 mL, 1.25 mmol, Sigma Aldrich) in DCM (20 mL). The reaction was heated to reflux for 15 h, and then cooled to RT. The solvent was removed to give the crude product 1.5 g. MS (ESI, pos. ion) m/z: 376.9 (M+1).

1. temperatureThe reaction was heated
2. temperatureto reflux for 15 h
3. customThe solvent was removed