HRID1056464

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCC=CCCCCCCCCOCC(CN(C)C)OCCCCCCCCC=CCCCCCCCC

HCID53844259

未命名化合物

HCID86643553

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCC=CCCCCCCCCOCC(C[N+](C)(C)CCCCC(=O)OCCC(=O)CCC(=O)CCC(C)=O)OCCCCCCCCC=CCCCCCCCC.[Br-]

HCID86643551

未命名化合物

收率 44%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

A mixture of 4 (430 mg, 0.69 mmol) and 6 (252 mg, 0.8 mmol) in acetone (5 ml) was stirred in a sealed-tube at RT for 24 h and than at 80° C. for another 24 h. After cooling, the solvent was evaporated in vacuo. Purification by flash chromatography on silica (10% methanol in dichloromethane) gave ME53 as an orange oil (264 mg, 44%).

WORKUP

后处理

temperatureAfter cooling
customthe solvent was evaporated in vacuo
customPurification by flash chromatography on silica (10% methanol in dichloromethane)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79f437c7fc2c44a199d282ec9feac429
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09399016B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH2:1]([O:19][CH:20]([CH2:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:21][N:22]([CH3:24])[CH3:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[O:45]=[C:46]([CH2:57][CH2:58][C:59](=[O:65])[CH2:60][CH2:61][C:62](=[O:64])[CH3:63])[CH2:47][CH2:48][O:49][C:50](=[O:56])[CH2:51][CH2:52][CH2:53][CH2:54][Br:55]>CC(C)=O>[Br-:55].[CH2:1]([O:19][CH:20]([CH2:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:21][N+:22]([CH2:54][CH2:53][CH2:52][CH2:51][C:50]([O:49][CH2:48][CH2:47][C:46](=[O:45])[CH2:57][CH2:58][C:59](=[O:65])[CH2:60][CH2:61][C:62](=[O:64])[CH3:63])=[O:56])([CH3:24])[CH3:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]