1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]- → (2,3-Bis-octadec-9-enyloxypropyl)-(3,6,9-trioxodecyloxycarbonylbutyl)-dimethylammonium bromide

Participants

Reaction Conditions

Reaction Steps

A mixture of 4 (430 mg, 0.69 mmol) and 6 (252 mg, 0.8 mmol) in acetone (5 ml) was stirred in a sealed-tube at RT for 24 h and than at 80° C. for another 24 h. After cooling, the solvent was evaporated in vacuo. Purification by flash chromatography on silica (10% methanol in dichloromethane) gave ME53 as an orange oil (264 mg, 44%).

Provenance & Evidence