HRID1056465

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCC=CCCCCCCCCOCC(CN(C)C)OCCCCCCCCC=CCCCCCCCC

HCID53844259

未命名化合物

结构：O=C(CCO)CCC(=O)CCC(=O)CCC(=O)CCC(=O)CCOC(=O)CCCCBr

HCID86643556

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCC=CCCCCCCCCOCC(C[N+](C)(C)CCCCC(=O)OCCC(=O)CCC(=O)CCC(=O)CCC(=O)CCC(=O)CCO)OCCCCCCCCC=CCCCCCCCC.[Br-]

HCID86643554

未命名化合物

收率 47%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

A mixture of 4 (395 mg, 0.64 mmol) and 8 (330 mg, 0.74 mmol) in acetone (5 ml) was stirred in a sealed-tube at RT for 24 h and than at 80° C. for another 24 h. After cooling, the solvent was evaporated in vacuo. Purification by flash chromatography on silica (gradient; 5% to 10% methanol in dichloromethane) gave ME52 as an orange oil (300 mg, 47%).

WORKUP

后处理

temperatureAfter cooling
customthe solvent was evaporated in vacuo
customPurification by flash chromatography on silica (gradient; 5% to 10% methanol in dichloromethane)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd03723186df40abae31207a31730556
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09399016B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH2:1]([O:19][CH:20]([CH2:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:21][N:22]([CH3:24])[CH3:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[OH:45][CH2:46][CH2:47][C:48](=[O:75])[CH2:49][CH2:50][C:51](=[O:74])[CH2:52][CH2:53][C:54](=[O:73])[CH2:55][CH2:56][C:57](=[O:72])[CH2:58][CH2:59][C:60](=[O:71])[CH2:61][CH2:62][O:63][C:64](=[O:70])[CH2:65][CH2:66][CH2:67][CH2:68][Br:69]>CC(C)=O>[Br-:69].[CH2:1]([O:19][CH:20]([CH2:25][O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH:35]=[CH:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:21][N+:22]([CH2:68][CH2:67][CH2:66][CH2:65][C:64]([O:63][CH2:62][CH2:61][C:60](=[O:71])[CH2:59][CH2:58][C:57](=[O:72])[CH2:56][CH2:55][C:54](=[O:73])[CH2:53][CH2:52][C:51](=[O:74])[CH2:50][CH2:49][C:48](=[O:75])[CH2:47][CH2:46][OH:45])=[O:70])([CH3:24])[CH3:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[CH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]