1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]- → (2,3-Bis-octadec-9-enyloxypropyl)-(17-hydroxy-3,6,9,12,15-pentaoxoheptadecyl-oxycarbonylbutyl)-dimethylammonium bromide

Participants

Reaction Conditions

Reaction Steps

A mixture of 4 (395 mg, 0.64 mmol) and 8 (330 mg, 0.74 mmol) in acetone (5 ml) was stirred in a sealed-tube at RT for 24 h and than at 80° C. for another 24 h. After cooling, the solvent was evaporated in vacuo. Purification by flash chromatography on silica (gradient; 5% to 10% methanol in dichloromethane) gave ME52 as an orange oil (300 mg, 47%).

Provenance & Evidence