Sec-Butylamine → HCID 43082197, compound

HRID 1056489Notes

Reaction equation

HRID 1056489 reaction equation
Cl[S:2]([C:5]1[CH:6]=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[CH:15]([NH2:19])([CH2:17][CH3:18])[CH3:16].CCN(C(C)C)C(C)C>C(Cl)Cl>[CH:15]([NH:19][S:2]([C:5]1[CH:6]=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3])([CH2:17][CH3:18])[CH3:16]

Participants

5

Reactant 3

HCID 24874Sec-ButylamineHCID 81531DiisopropylethylamineHCID 6089842-Fluoro-5-chlorosulfonylbenzoic acid

Product 1

HCID 43082197HCID 43082197, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-Chlorosulfonyl-2-fluoro-benzoic acid (A, 0.506 g, 0.0021 mol), sec-butylamine (E, 0.155 g, 0.00212 mol) and DIEA (1.1 mL, 0.00636 mol) in CH2Cl2 were stirred at room temperature overnight. The solvent was evaporated and the crude product was purified by silica gel chromatography (MeOH containing 10% AcOH)/CH2Cl2) to give 5-sec-Butylsulfamoyl-2-fluoro-benzoic acid (F, 0.56 g, 96%). After drying overnight under vacuum, F (0.56 g, 0.0020 mol) in SOCl2 (5 mL) was heated at 80° C. for 3 hours, after which the SOCl2 was evaporated and the residue was dried overnight. The residue was then dissolved in tetrahydrofuran (5 mL), 3,4-difluoro-phenylamine (D, 0.26 g, 0.0020 mol) was added followed by DIEA (0.8 mL). The mixture was heated to 70° C. overnight. The solvent was evaporated, followed by ethyl acetate extraction. After purification by silica gel chromatography (ethyl acetate/hexane), 0.45 g (57%) of 5-sec-butylsulfamoyl-N-(3,4-difluoro-phenyl)-2-fluoro-benzamide (DVR-23) was obtained.

Workup

  1. customThe solvent was evaporated
  2. customthe crude product was purified by silica gel chromatography (MeOH containing 10% AcOH)/CH2Cl2)

Sources & evidence

ORD record
ord-172d97d9d96340c091a8601967fccc3d
Source dataset
uspto-grants-2016_07
Patent number
US09399619B2

Reaction notes

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