Pyridine → 1-Chloroethyl Cyclohexyl Carbonate

HRID 1056596Notes

Reaction equation

HRID 1056596 reaction equation
[C:1](Cl)(=[O:6])[O:2][CH:3]([Cl:5])[CH3:4].[CH:8]1([OH:14])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.N1C=CC=CC=1>C(Cl)Cl>[C:1](=[O:6])([O:14][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[O:2][CH:3]([Cl:5])[CH3:4]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7966CyclohexanolHCID 5213051-Chloroethyl chloroformate

Product 1

HCID 112295291-Chloroethyl Cyclohexyl Carbonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared according to the procedure as described in Example 26 step 1 using a solution of 1-chloroethyl carbonochloridate (5 g, 35 mmol) in DCM (100 mL), cyclohexanol (3.9 g, 38.5 mmol) and pyridine (3.3 g, 42 mmol). The title compound was obtained as colorless oil (7 g, 96.9%) and was used in the next step without further purification. The title compound was characterized by 1H NMR as shown below:

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9258106188374deb988d8ff5a7c01b71
Source dataset
uspto-grants-2016_07
Patent number
US09399639B2

Reaction notes

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