HCID 90009967, compound → HCID 72190844, compound

HRID 1056618Notes

Reaction equation

HRID 1056618 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:25]2[O:26][C:27](=[O:31])[N:28]([CH3:30])[N:29]=2)[C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:24])[C:16]3[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=3[F:23])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.C(O[C:35](=O)[C:36]1[CH:41]=C(Br)C=NC=1C1C=CC(NC(=O)C2C(F)=CC=CC=2F)=CC=1)C>>[CH:41]1([C:2]2[CH:3]=[C:4]([C:25]3[O:26][C:27](=[O:31])[N:28]([CH3:30])[N:29]=3)[C:5]([C:8]3[CH:9]=[CH:10][C:11]([NH:14][C:15](=[O:24])[C:16]4[C:17]([F:23])=[CH:18][CH:19]=[CH:20][C:21]=4[F:22])=[CH:12][CH:13]=3)=[N:6][CH:7]=2)[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 90009967HCID 90009967, compoundHCID 90010642HCID 90010642, compound

Product 1

HCID 72190844HCID 72190844, compound

Procedure

Step-4: N-(4-(5-Bromo-3-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyridin-2-yl)phenyl)-2,6-difluorobenzamide: The title compound was prepared from ethyl-5-bromo-2-(4-(2,6-difluorobenzamido)phenyl)nicotinate by following the similar procedure sequentially as described in step-2, step-3, and step-4 of Intermediate-1a. ESI-MS (m/z) 487, 489 [(MH)+, Br79,81].

Sources & evidence

ORD record
ord-d745bc29b09a4a9396ad65d65f9fdd2f
Source dataset
uspto-grants-2016_07
Patent number
US09399638B2

Reaction notes

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