反应详情

温度

100 °C

To a solution of 2,4-dichloro-5-methyl-pyrimidine (0.58 g, 3.60 mmol) and tert-butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate (1.44 g, 5.37 mmol) in EtOH (25 mL) was added Et3N (0.86 g, 8.50 mmol). After addition, the reaction mixture was stirred at 100° C. in a sealed tube for 25.5 h and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/2) to give the title compound as a yellow solid (332.2 mg, 24%).

1. additionAfter addition
2. concentrationconcentrated in vacuo
3. customThe residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/2)