Cesium carbonate → tert-butyl 9-((2-((2,3-dimethyl-2H-indazol-6-yl)amino)-5-methylpyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate

HRID 1056649Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:26][CH2:25][C:12]3([CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]3)[CH2:11][CH2:10]2)[C:5]([CH3:27])=[CH:4][N:3]=1.Cl.[CH3:29][N:30]1[C:38]([CH3:39])=[C:37]2[C:32]([CH:33]=[C:34]([NH2:40])[CH:35]=[CH:36]2)=[N:31]1.C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C(O[Pd]OC(=O)C)(=O)C>[CH3:29][N:30]1[C:38]([CH3:39])=[C:37]2[C:32]([CH:33]=[C:34]([NH:40][C:2]3[N:7]=[C:6]([NH:8][CH:9]4[CH2:10][CH2:11][C:12]5([CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[CH2:16][CH2:17]5)[CH2:25][CH2:26]4)[C:5]([CH3:27])=[CH:4][N:3]=3)[CH:35]=[CH:36]2)=[N:31]1

Participants

Conditions

Temperature: 150 °C

Procedure

A mixture of tert-butyl 9-((2-chloro-5-methylpyrimidin-4-yl)amino)-3-azaspiro[5.5]undecane-3-carboxylate (1.2 g, 3.0 mmol), 2,3-dimethylindazol-6-amine hydrochloride (896.5 mg, 4.536 mmol), diacetoxypalladium (132.4 mg, 0.5898 mmol), BINAP (370.3 mg, 0.5947 mmol) and dicesium carbonate (2.98 g, 9.15 mmol) was dissolved in anhydrous dioxane (10 mL). The reaction mixture was stirred under microwave irradiation at 150° C. for 2 h and then concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=30/1) to give the title compound as a yellow solid (1.04 g, 66%).

Workup

concentrationconcentrated in vacuo
customThe residue was purified by silica gel column chromatography (DCM/MeOH (v/v)=30/1)

Sources & evidence

ORD record: ord-55fd4c9b2b0f4954b1eaf4908d6c6dad
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09399637B2

Reaction notes

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