Diisopropylethylamine → HCID 118566636, compound

HRID 1056729Notes

Reaction equation

HRID 1056729 reaction equation
[F:1][C:2]1([F:25])[CH2:7][CH2:6][C:5]([CH2:9][NH:10][C:11]([C:13]2[C:14]3[CH:15]=[CH:16][C:17](Cl)=[N:18][C:19]=3[CH:20]=[CH:21][C:22]=2[Cl:23])=[O:12])(O)[CH2:4][CH2:3]1.CC[N:28]([CH:32]([CH3:34])C)[CH:29]([CH3:31])C.[OH:35][CH2:36][CH2:37]C1CCNC1>>[F:1][C:2]1([F:25])[CH2:7][CH2:6][CH:5]([CH2:9][NH:10][C:11]([C:13]2[C:14]3[CH:15]=[CH:16][C:17]([N:28]4[CH2:29][CH2:31][CH:34]([CH:36]([OH:35])[CH3:37])[CH2:32]4)=[N:18][C:19]=3[CH:20]=[CH:21][C:22]=2[Cl:23])=[O:12])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 126124412-(Pyrrolidin-3-yl)ethan-1-olHCID 1185560922,6-Dichloro-quinoline-5-carboxylic acid (4,4-difluoro-1-hydroxy-cyclohexylmethyl)-amide

Product 1

HCID 118566636HCID 118566636, compound

Procedure

The title compound was synthesized according to the procedure described in example 1 using 2,6-dichloro-quinoline-5-carboxylic acid (4,4-difluoro-1-hydroxycyclohexylmethyl)-amide, DIPEA and 3-hydroxyethyl-pyrrolidine. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.75 (1H), 7.48 (2H), 6.69 (1H), 4.62 (m, 1H), 3.71-3.66 (m, 2H), 3.49 (m, 2H), 3.32 (m, 2H), 2.44 (m, 2H), 2.06 (m, 2H), 1.85 (m, 2H), 1.74-1.76 (m, 5H), 1.30 (m, 2H), 1.13 (m, 3H). m/z: 452 [M+H]

Sources & evidence

ORD record
ord-15b4ecd600ad4d0695db6a773045d902
Source dataset
uspto-grants-2016_07
Patent number
US09399623B2

Reaction notes

Loading…