反应详情

温度

57.5 °C

A 1.0 M solution of hydrogen chloride in water (2.3 mL, 2.3 mmol) was added to a suspension of iron (1.28 g, 23.0 mmol) (<10 μm) in ethanol (25.1 mL) and the resultant suspension was stirred at 60° C. for 2 h. The reaction mixture was then cooled to 55-60° C. and treated with a 5.0 M solution of ammonium chloride in water (3950 μL, 19.8 mmol), followed by the addition of 4-bromo-3-methoxy-N-methyl-2-nitroaniline (1.20 g, 4.60 mmol) as a solid. The flask containing 4-bromo-3-methoxy-N-methyl-2-nitroaniline was rinsed with ethanol (3.75 mL) and the solution was added to the reaction mixture. The resultant reaction mixture was stirred at 60-65° C. for 2 h, after which time the reaction mixture was diluted with ethyl acetate (100 mL), treated with anhydrous magnesium sulfate, stirred for 10 min and then filtered through a pad of Celite. The filtrate was concentrated to dryness in vacuo and the resulting solid was used immediately without further purification. The crude bis-aniline was dissolved in tetrahydrofuran (32.0 mL), treated with N,N-carbonyldiimidazole (1.86 g, 11.5 mmol) and stirred at RT overnight. The reaction mixture was diluted with ethyl acetate and water. Layers were separated and the organic layer was washed with brine, dried with magnesium sulfate, filtered, and concentrated in vacuo to give the crude product. Purification by flash column chromatography (100% hexanes to 30% EtOAc/hexanes to 100% EtOAc) gave the desired product (1.05 g, 89%) as a solid. LCMS calculated for C9H10BrN2O2 (M+H)+: m/z=257.0, 259.0. found: 257.1, 259.1.

1. washwas rinsed with ethanol (3.75 mL)
2. additionthe solution was added to the reaction mixture
3. customThe resultant reaction mixture
4. stirringstirred for 10 min
5. filtrationfiltered through a pad of Celite
6. concentrationThe filtrate was concentrated to dryness in vacuo
7. customthe resulting solid was used immediately without further purification
8. dissolutionThe crude bis-aniline was dissolved in tetrahydrofuran (32.0 mL)
9. stirringstirred at RT overnight
10. customLayers were separated
11. washthe organic layer was washed with brine
12. dry with materialdried with magnesium sulfate
13. filtrationfiltered
14. concentrationconcentrated in vacuo
15. customto give the crude product
16. customPurification by flash column chromatography (100% hexanes to 30% EtOAc/hexanes to 100% EtOAc)