Dichloromethane → 7-(2-Carboxyvinyl)-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline

HRID 105704Notes

Reaction equation

HRID 105704 reaction equation
[CH2:31]([Cl:32])[Cl:33].[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([CH:19]=[CH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:28][cH:29]1.[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[Cl:1][c:2]1[cH:3][c:4]([F:30])[c:5]([O:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([CH:19]=[CH:20][C:21](=[O:22])[OH:23])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:28][cH:29]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 540046344-(4-Chloro-2-fluorophenoxy)-6-methoxy-7-(2-(tert-butoxycarbonyl)vinyl)quinazoline

Product 1

HCID 541944267-(2-Carboxyvinyl)-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline

Sources & evidence

ORD record
ord-0bf8caa367e64fc6bdf2e221a7aa8839
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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