Iodobenzene → (E)-5-(1-(4-Bromophenyl)-2-phenylbut-1-en-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

HRID 1057211Notes

Reaction equation

HRID 1057211 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][O:15]1)[N:9]=[CH:8]2)#[C:2][CH2:3][CH3:4].I[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[Br:27][C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1>>[Br:27][C:28]1[CH:33]=[CH:32][C:31](/[C:1](/[C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[N:10]([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][O:15]2)[N:9]=[CH:8]3)=[C:2](\[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)/[CH2:3][CH3:4])=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 11575IodobenzeneHCID 79599(4-Bromophenyl)boronic acidHCID 667932705-(But-1-yn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Product 1

HCID 66802799(E)-5-(1-(4-Bromophenyl)-2-phenylbut-1-en-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Procedure

The title compound was prepared from Intermediate 3, iodobenzene, and (4-bromophenyl)boronic acid following General Procedure C. LCMS: 403 [(M-THP+H)+H]+.

Sources & evidence

ORD record
ord-fc7e6c27686a4555b810bdb3fa449b38
Source dataset
uspto-grants-2016_07
Patent number
US09399646B2

Reaction notes

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