Benzonitrile, 4-bromo- → HCID 12056689, compound

HRID 1057278Notes

Reaction equation

HRID 1057278 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[F:10][C:11]([F:31])([C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[C:12]([N:14]=[C:15]([C:20]([F:23])([F:22])[F:21])[C:16]([F:19])([F:18])[F:17])=[O:13]>C(OCC)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]2[O:13][C:12]([C:11]([F:10])([F:31])[C:24]([F:29])([F:30])[C:25]([F:27])([F:28])[F:26])=[N:14][C:15]([C:20]([F:23])([F:22])[F:21])([C:16]([F:19])([F:18])[F:17])[N:7]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 12162Benzonitrile, 4-bromo-HCID 13267233HCID 13267233, compound

Product 1

HCID 12056689HCID 12056689, compoundYield 100.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
60 °C

Procedure

4-Bromobenzonitrile (0.3 g, 1.65 mmol) and 2,2,3,3,4,4,4-heptafluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl)ethylidene}butanamide (1.2 g, 3.3 mmol) were dissolved in diethyl ether (4.0 mL) and heated in a sealed glass tube to 60° C. for 17 hours. The solvent and excess reagent were distilled off to give a colorless liquid (0.9 g, 100 percent yield). EIMS (m/z): 543 (M+), 524 (M-F), 474 (M-CF3).

Workup

  1. distillationThe solvent and excess reagent were distilled off

Sources & evidence

ORD record
ord-dc630837cde94e44b52dd130d08c6bcb
Source dataset
uspto-grants-2003_02
Patent number
US06514911B1

Reaction notes

Loading…