Trifluoroacetic acid → HCID 7020604, compound

HRID 1057302Notes

Reaction equation

HRID 1057302 reaction equation
[NH:1]([C:17]([O:19][CH2:20][CH:21]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27]2[C:22]1=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:18])[C@H:2]([C:11]([O:13][CH2:14][CH:15]=[CH2:16])=[O:12])[CH2:3][C:4](=[O:10])[O:5]C(C)(C)C.FC(F)(F)C(O)=O>>[NH:1]([C:17]([O:19][CH2:20][CH:21]1[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:28]2[C:33]1=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:18])[C@H:2]([C:11]([O:13][CH2:14][CH:15]=[CH2:16])=[O:12])[CH2:3][C:4](=[O:5])[OH:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11662410HCID 11662410, compound

Product 1

HCID 7020604HCID 7020604, compound

Procedure

FmocAsp(OtBu)OAllyl (40 g, 88.7 mmol) was treated with 25 ml of trifluoroacetic acid and the mixture was stirred at room temperature for 30 min. The solvent was stripped off on a rotary evaporator. The residue was dried in vacuo. FmocAsp(OH)OAllyl was obtained as a yellow oil (33.9 g, 97%).

Workup

  1. customThe solvent was stripped off on a rotary evaporator
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-7b226c8a1baa4b7c9bfbca26ac0e75c2
Source dataset
uspto-grants-2003_02
Patent number
US06514952B1

Reaction notes

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