反应详情

Tetrakis(triphenylphosphine)palladium (1 g) was added to a mixture of 5 g of 4-methoxyphenylboronic acid, 6,6 g of 5-bromo-2-fluoronitrobenzene and 30 mL of 2 M sodium carbonate solution in 50 mL of toluene and 50 mL of ethanol. The mixture was heated to refulux for 2 hours, concentrated, and the residue extracted twice with ethyl acetate. The ethyl acetate layer was washed with water, brine, dried, and concentrated to give a brown oily solid. The solid was chromatographed on silica gel in 5% ethyl acetate in hexane to give crude 4-fluoro-4′-methoxy-3-nitrobiphenyl as a pale yellow solid.

1. temperatureThe mixture was heated
2. concentrationconcentrated
3. extractionthe residue extracted twice with ethyl acetate
4. washThe ethyl acetate layer was washed with water, brine
5. customdried
6. concentrationconcentrated
7. customto give a brown oily solid
8. customThe solid was chromatographed on silica gel in 5% ethyl acetate in hexane