HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-(2-Pyridylamino)heptanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | 7-Aminoheptanoic acid | HCID 13580 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 7-(2-Pyridylamino)heptanoic acid | HCID 18671389 | — |
Reaction Steps
To a stirring solution of 7-aminoheptanoic acid in pyridine (0.5 M) was added 2-fluoropyridine (2 eq) and 2N NaOH (1 eq), and the reaction was refluxed overnight. The mixture was adjusted to neutral pH with 6N HCl and concentrated in vacuo. The residue was suspended in 10:1:1 EtOH/NH4OH/H2O, filtered through a plug of silica, and concentrated in vacuo to afford a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514964B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-02f2540348bf455fac9a3858e825fa23 |
| Source note | uspto-grants-2003_02 |