反应详情

To a stirring solution of 7-aminoheptanoic acid in pyridine (0.5 M) was added 2-fluoropyridine (2 eq) and 2N NaOH (1 eq), and the reaction was refluxed overnight. The mixture was adjusted to neutral pH with 6N HCl and concentrated in vacuo. The residue was suspended in 10:1:1 EtOH/NH4OH/H2O, filtered through a plug of silica, and concentrated in vacuo to afford a colorless solid.

1. temperaturethe reaction was refluxed overnight
2. concentrationconcentrated in vacuo
3. filtrationfiltered through a plug of silica
4. concentrationconcentrated in vacuo
5. customto afford a colorless solid