(2-Bromo-5-nitrophenyl)methanol → 2-Bromo-5-nitrobenzaldehyde

HRID 1057509Notes

Reaction equation

HRID 1057509 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][OH:12].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH:11]=[O:12]

Participants

4

Reactant 2

HCID 18671373(2-Bromo-5-nitrophenyl)methanolHCID 178418287HCID 178418287, compound

Product 1

HCID 111389422-Bromo-5-nitrobenzaldehyde

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of (2-bromo-5-nitrophenyl) methan-1-ol (1 eq) in methylene chloride (0.1 M) at room temperature was added pyridinium chlorochromate (2 eq). After 2 hr the reaction mixture was filtered through celite and the product was purified by flash chromatography (15% EtOAc/Hexane). EI-MS m/z 230 (M+H)+.

Workup

  1. filtrationAfter 2 hr the reaction mixture was filtered through celite
  2. customthe product was purified by flash chromatography (15% EtOAc/Hexane)

Sources & evidence

ORD record
ord-fbc384056f684647b99603fc08343c51
Source dataset
uspto-grants-2003_02
Patent number
US06514964B1

Reaction notes

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