Potassium Iodide → 3-Cyclohexyl-1-[4-[4-[2-(2-propyloxy)phenyl]-1,2,3,6-tetrahydropyridin-1-yl]butan-1-yl]-2-imidazolidinone oxalate

HRID 1057668Notes

Reaction equation

HRID 1057668 reaction equation
[CH3:1][CH:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1)[CH3:3].Cl[CH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:26][CH2:25][N:24]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:23]1=[O:33].[C:34](=O)([O-:36])[O-:35].[K+].[K+].[I-].[K+]>CC(CC(C)=O)C>[C:23]([OH:33])(=[O:4])[C:34]([OH:36])=[O:35].[CH:27]1([N:24]2[CH2:25][CH2:26][N:22]([CH2:21][CH2:20][CH2:19][CH2:18][N:14]3[CH2:13][CH:12]=[C:11]([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH:2]([CH3:1])[CH3:3])[CH2:16][CH2:15]3)[C:23]2=[O:33])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 186721001-(4-Chloro-1-butyl)-3-cyclohexyl-2-imidazolidinoneHCID 186721214-[2-(2-Propyloxy)phenyl]-1,2,3,6-tetrahydropyridine

Product 1

HCID 186720883-Cyclohexyl-1-[4-[4-[2-(2-propyloxy)phenyl]-1,2,3,6-tetrahydropyridin-1-yl]butan-1-yl]-2-imidazolidinone oxalate

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

A mixture of 4-[2-(2-propyloxy)phenyl]-1,2,3,6-tetrahydropyridine 8a (2.3 g), 1-(4-chloro-1-butyl)-3-cyclohexyl-2-imidazolidinone 1a (1.25 g), potassium carbonate (1.6 g) and a potassium iodide crystal in MIBK (60 ml) was refluxed overnight.

Sources & evidence

ORD record
ord-bf2e43ae671d415e9658660de5e61f98
Source dataset
uspto-grants-2003_02
Patent number
US06514993B1

Reaction notes

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