HRID1057668

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

HCID11430

Potassium Carbonate

CK2O3

HCID18672100

1-(4-Chlorobutyl)-3-cyclohexyl-2-imidazolidinone

C13H23ClN2O

HCID18672121

1,2,3,6-Tetrahydro-4-[2-(1-methylethoxy)phenyl]pyridine

C14H19NO

PRODUCTS

产物

反应SMILES：CC(C)Oc1ccccc1C1=CCN(CCCCN2CCN(C3CCCCC3)C2=O)CC1.O=C(O)C(=O)O

HCID18672088

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID7909

4-Methyl-2-pentanone

C6H12O

PROCEDURE

实验过程

A mixture of 4-[2-(2-propyloxy)phenyl]-1,2,3,6-tetrahydropyridine 8a (2.3 g), 1-(4-chloro-1-butyl)-3-cyclohexyl-2-imidazolidinone 1a (1.25 g), potassium carbonate (1.6 g) and a potassium iodide crystal in MIBK (60 ml) was refluxed overnight.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bf2e43ae671d415e9658660de5e61f98
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06514993B1
来源说明: uspto-grants-2003_02

反应SMILES

[CH3:1][CH:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1)[CH3:3].Cl[CH2:18][CH2:19][CH2:20][CH2:21][N:22]1[CH2:26][CH2:25][N:24]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:23]1=[O:33].[C:34](=O)([O-:36])[O-:35].[K+].[K+].[I-].[K+]>CC(CC(C)=O)C>[C:23]([OH:33])(=[O:4])[C:34]([OH:36])=[O:35].[CH:27]1([N:24]2[CH2:25][CH2:26][N:22]([CH2:21][CH2:20][CH2:19][CH2:18][N:14]3[CH2:13][CH:12]=[C:11]([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH:2]([CH3:1])[CH3:3])[CH2:16][CH2:15]3)[C:23]2=[O:33])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1